Malaria. It's a jerk. And so widespread that trying to cure the infected human population is a monumental task.
So why not just cure the vector for it?
Scientists created a malaria-blocking bacterium and infected mosquitoes with it, creating a malaria-immune population of mosquitoes in 8 generations.
No need to hunt down every at-risk human population and cure or inoculate them. Just stop it at the source and let evolution and a new microflora in the vector population handle it. Science is so cool.
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